Tabtoxin and Tabtoxinine-p-lactam

Tabtoxin is an exotoxin of the phytopathogenic bacterium Pseudomonas tabaci, first isolated in 1952, and induces the wildfire disease, a leaf-spot disease, on tobacco plants [41]. The structure of tabtoxin 27 was reported almost 20 years later [42], 

Unlike most known BLAs, which affect bacterial cell wall synthesis, 28 irreversibly inhibits glutamine synthetase, thus rendering the cell incapable of reassimilating the ammonia released by normal photorespiration. Toxic concentrations of 

FOUR-MEMBERED HETEROCYCLIC RINGS AND THEIR FUSED DERIVATIVES 

1 3 tabP tabB tbIA tbIS tbID tbIF 16 18 20 

2 tabD tabA tabC tblC tblE tblR 17 19 

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