Tables of Specific Compounds

In Tables I and II, the known types of 4-acetoxy-, 4-alkoxy-, and 4-hydroxy-l,2,3,4-tetrahydroisoquinolines are indicated. Table III summarizes the known 4-keto-l,2,3,4-tetrahydroisoquinolines. In Tables IV and V, the various classes of 1,2,3,4-tetrahydroisoquinolines and aromatic isoquinolines which have been made by the methods discussed in this article are given. In Tables VI and VII, the 4-phenyl-l,2,3,4-tetrahydroisoquinolines and bicyclic compounds made by nucleophilic displacement of the 4-hydroxy group are summarized. Twenty-four compounds e.g., (31-40) prepared from 30 with active CH,78 NH, and SH77 compounds have been reported details may be found in the references cited. 

In each table, the chief synthetic routes are indicated by the equation numbers in the text. 

The various compounds that can be made from 4-hydroxytetra-hydroisoquinolines via 1,2-dihydroisoquinolines [Eq. (32)] have been listed by Dyke.71 

The author would like to thank the National Cancer Institute of the National Institutes of Health (Grants CA-3437 and CA-3905) and the Department of the Army (Contract DA-49-193-MD-2948 of the antimalarials program) for financial support of his isoquinoline work over the years. He would like to thank Professor R. D. Topsom and LaTrobe University for their hospitality while the author wrote a portion of this paper. 

Kline and French Laboratories, Philadelphia, unpublished results. 

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