T-Phos

The hydrogenation of a series of E/Z-isomeric mixtures of a-arylenamides with a MOM-protected /1-hydroxyl group catalyzed by a Rh-complex of 1,4-dipho-sphane T-Phos with a rigid 1,4-dioxane backbone led to chiral / -amino alcohol derivatives in excellent enantioselectivities (Scheme 26.4) [55]. DIOP -Rh is also effective for this transformation [51b]. 

The hydrogenation of a series of T/Z-isomeric mixtures of a-arylenamides containing a MOM-protected /9-hydroxyl group, using BICP-Rh and Me-DuPhos-Rh catalysts, affords the /9-amino alcohol derivatives with excellent enantioselectivity [41c]. A 1,4-di-phosphane, T-Phos, with a rigid 1,4-dioxane backbone is also a very effective Hgand for this transformation (Eq. 11) [45]. 

SUGA K, KAMBAYASm J, KAWASAKI T, SAKON M, MORI T. Pho )h ylation of phosphoinositides in humanplatdets. ThrombRes44 155-163,1986. 

Scheme 9.10 Rh catalyzed asymmetric hydrogenation of MOM protected 3 hydroxy a arylenamides 26 with (R,R) BICP and (S,S,S,S) T Phos.

The correlation in Fig. 21.5 gives values that are too low for creeping flow, where the Reynolds number is low and the Peclet number Np is high (A p = = T>pHo/ y) For this case the recommended equation is ... 

Zhang has developed a series of 1,4-diphosphane ligands with a conformationally rigid 1,4-dioxane backbone, as exemplified by T-Phos 36 and SK-Phos 37. These ligands have proved highly efficient and selective (> 99% ee) for the asymmetric hydrogenation of arylenamides and MOM-protected p-hydroxyl enamides.33... 

HheN n) dnno t)Pho t)ufio t) is the total variable costs of aU the... 

Gennaro (51) proposed a method for the separation of water-soluble vitamins by means of the ion interaction reagent using octylamine < -phosphate or octylamine salicylate buffer (at pH 6.4) as the interaction reagent and the mobile phase at a flow rate of 1 mL/min, and a 2.5-p.m Spherisorb ODS C18 column (250 X 4.6 mm) as the stationary phase. The column effluent was monitored at 210 nm. Retention times of pantothenic acid obtained with octylamine t)-phos-phate and octylamine salicylate were 64.0 and 9.8 min. The method was used for the determination of pantothenic acid in a model mixture of water-soluble vitamins and also in a commercial multivitamin isotonic salt dietetic drink (Fig. 9). 

Liewluck T, Pho-Iam T, Limwongse C et al. (2006) Mutation analysis of the GNE gene in distal myopathy with rimmed vacuoles (DMRV) patients in Thailand. Muscle Nerve 34, 775-778. 

Both CpTl and Cp2Hg react with (12) to produce only one isomer (13) (Y = C=CR, L = t-phos). " CpTl and (13) (Y = Ph, L = t-phos) behave similarly. Treatment of (13) (Y = C=CR or Ph) with HgCl2 or cis-[PtCl2(CO)L] also involves reaction of the group trans to L, the Cp ligand being transferred and (12) formed. These systems conform to the pattern expected for an S 2(cyclic) mechanism. A reaction involving Hg(C=CMe)2 is more complicated. 

Louie, B. M., T. Franaszek, T. Pho, W. Y. Chiu, and D. S. Soong, Control of Free-Radical Emulsion Pol3mierization of Methyl Methacrylate by Oxygen Injection II. Experimental Study, J. Appl. Polym. Sci., 30, 3841-3856, 1985. 

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