T-B cooperation

After a single oral dose of 50 mg to 26 subjects, a mean peak serum-amoxapine concentration of 0.03 ig/ml was attained in 1 to 2 hours the peak concentration of 8-hydroxyamoxapine was of a similar order (T. B. Cooper and R. G. Kelly, idem.). 

Following a single oral dose of 30 mg to 1 subject, a peak plasma concentration of 0.002 pg/ml was attained in 2 hours. In a subject who had been receiving daily oral doses of 30 mg for 6 weeks, a trough steady-state plasma concentration of 0.0002 pg/ml was reported (T. B. Cooper et al., Commun. PsychopharmacoL, 1978, 2, 505-512). 

High Pressure Liquid Chromatography. In plasma trimipramine and metabolites, sensitivity 3 ng/ml, electrochemical detection—R. F. Suckow and T. B. Cooper, J.pharm. Sci., 1984, 73, 1745-1748. 

Fig. 1. Schematic representation of the possible reactions of the immune system to drugs. A drug is probably presented as antigen most efficiently after binding to macrophage membranes and interacting with T-helper lymphocytes, which may either generate effector-sensitized T-lymphocytes or cooperate with B-l3miphocytes in the production of antidrug antibodies. This scheme of T/B cooperation is extremely oversimplified, since the various circuits of T-helper and suppressor cells are not represented (Germain et al. 1981)...

R.F. Suckow and T.B. Cooper, Simultaneous determination of imipramine, desipramine, and their 2-hydroxy metabolites in plasma by ion-pair reversed-phase high-performance liquid chromatography with amperometric detection, J. Pharm. Sci., 1981, 70, 257-261. 

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