Systemic Lupus Activity Measure

The underlying rationale for early application of SBC-5-IMNs in LN is that once renal damage occurs, progressive damage will follow if the disease activity remains high (Systemic Lupus Activity Measure or SLAM score > 4). Indications for therapy with SBC-5-IMNs in DMARD-Refractory LN (DR-LN) include ... 

Systemic Lupus Activity Measure (SLAM)/Revised SLAM (SLAM-R) Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)... 

Fig. 5. Serial study of a woman with systemic lupus erythematosus showing correlation among levels of immune complexes measured by the Raji assay, complement levels, antibodies to native DNA, and clinical activity. (Reproduced with permission, A. N. Theofilopoulos, C. B. Wilson, and F. J. Dixon,. Clin. Invest. 57, 169-182, 1976, by copyright permission of the American Society for Clinical Investigation.)...

Ruiz-lrastorza G, Khamashta MA, Gordon C, Lockshin MD, Johns KR, Sammaritano L, Hughes GR (2004) Measuring systemic lupus erythematosus activity during pregnancy validation of the lupus activity index in pregnancy scale. Arthritis Rheum, 51(1) 78-82. 

Elevated serum levels (3- to 5-fold) of MMP-3 have been demonstrated in patients with systemic lupus erythematosus, the prototype autoimmune disease, as compared to healthy controls. Contrary to anticipated results, serial measurements of MMP-3 in patients with SEE did not correlate with fluctuation in disease activity scores (Z12). Similar results were later reported by Keyszer et al. (K4). These data are consistent with the concept that MMP-3 is more related to the later tissue repair aspect, rather than to the initiating tissue injury process in SEE (Z12). If this assumption is correct, the use of MMP-inhibitory drugs may prove to be detrimental in diseases in which the... 

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