Systemic immunologic reactions to silicone

In humans, liquid silicone has been injected subcutaneously for cosmetic reasons. Granulomatous reactions have been reported to occur in some instances [14-17]. Similar reactions have been noted in two case reports following the rupture of silicone gel-filled breast prostheses [24,25]. Clinically, these reactions have the characteristics of an inflammatory response, i.e., redness, swelling, and pain. Histologic examination shows chronic inflammatory reactions, occasionally with the presence of refrac-tile material resembling silicone [24]. 

Systemic reactions have been reported following the introduction of silicone into the body. In one instance, a severe systemic reaction consisting of a febrile illness, acute renal insufficiency, respiratory compromise. 

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Immunologic reactions to silicone can be local, regional due to silicone migration, or systemic. Local cutaneous and subcutaneous reactions to... 

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