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System synthesis segment level

In order to further improve the solubility of uronium salts and to eliminate any absorbance in the range 300-350 nm as this will improve Fmoc-assisted monitoring of peptide synthesis, uronium compounds derived from the oxo-pyridine system have been synthe-sized. TPTU (16) has been recommended for segment condensations (low epimerization level),and couples A-methyl amino acids more efficiently than TBTU.f Uronium salt TOPPipU (40), although causing substantial epimerization, is unique in possessing significantly enhanced solubility (1.5 mol-L in DMF).t l... [Pg.559]


See other pages where System synthesis segment level is mentioned: [Pg.254]    [Pg.3]    [Pg.458]    [Pg.50]    [Pg.109]    [Pg.27]    [Pg.16]    [Pg.753]    [Pg.1416]    [Pg.582]    [Pg.3]    [Pg.316]    [Pg.39]    [Pg.3]    [Pg.458]    [Pg.166]    [Pg.417]    [Pg.434]    [Pg.324]    [Pg.222]    [Pg.366]    [Pg.170]    [Pg.39]    [Pg.1935]   
See also in sourсe #XX -- [ Pg.761 ]




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