Synthetic pharmacological agents

At present, many natural and synthetic chelators have been studied as potential pharmacological agents for the treatment of iron or copper overload under various pathophysiological conditions. (The chelating activity of flavonoids was already discussed above and the application of chelators in thalassemia and some other pathologies is considered in Chapter 31.) There are specific thermodynamic demands to chelators to be efficient antioxidants [369], We will consider just several chelators of potential therapeutic importance. 

It is not surprising to see that most of the bio-active compounds discussed in this review are 1,2-diazine derivatives bearing heteroatom substituents either at C-3 or at C-3 and C-6, since pyridazinones and pyridazinediones, utilized as intermediates in the synthesis of such derivatives, have been known for a long period and are generally conveniently accessible. On the other hand, there are so far only a few examples of pyridazine-derived pharmacological agents in which the parent system is linked to a functionalized carbon side-chain only. This may be attributed to the fact that many of the required synthetic building blocks had remained unexplored until very recently [15,173,438-441]). 

Pharmacology Linezolid is a synthetic antibacterial agent of oxazolidinones. The results of time-kill studies have shown linezolid to be bacteriostatic against enterococci and staphylococci. For streptococci, linezolid was found to be bactericidal for the majority of strains. 

Pharmacology Rimantadine is a synthetic antiviral agent that appears to exert its... 

As mentioned above, this third part of the plant psychedelic alkaloid world involves tetrahydroisoquinolines and is the substance of our third book. A very reasonable appendix to be written for this book would be a search of the chemical literature for the known isoquinolines that might be of interest as pharmacological agents. There are certainly many plant products, as well as a monster inventory of synthetics, some of which are made based on plant examples, but many others are simply laboratory creations of the imaginative chemist. 

---