Synthetic pathways, generated using

Recently, Meier et al. synthesized the most extended OP Vs (81) known to date [104]. Four different synthetic pathways were used for the generation of these OP Vs the final step involves the formation of one or two olefinic double bonds via a Wittig-Horner-type, a Siegrist-type or a McMurry-type condensation. 

Over the years a number of general synthetic pathways to silenes have been developed these have been employed by research groups to generate families of silenes closely related in structure. It seems useful to list the most common pathways, together with references, in Table I14-91 and then to comment on some of them in detail. 

The ultimate challenge for an efficient synthetic pathway to complex chiral target molecules is the generation of enantiomerically pure products either by use of enantiomerically pure starting materials or by application of... 

Design less hazardous chemical syntheses Design syntheses to use and generate substances with little or no toxicity to humans and the environment. A holistic view of a synthetic pathway often allows a chemist to change factors and minimize hazard in a number of steps simultaneously. A safer synthesis may simply reduce the number of isolations and purifications,... 

For generating synthetic pathways by a computer, representations for the intermediates of chemical syntheses (molecules) and for the transformation intermediates of these (reactions) have to be designed. Both molecules and reactions are represented in our model of constitutional chemistry4 5 by matrices. Internally, in the program, more compact forms are used. 

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