Synthetic Methodologies for the Construction of Cyclic 10-Membered Enediynes

2 SYNTHETIC METHODOLOGIES FOR THE CONSTRUCTION OF CYCLIC 10-MEMBERED ENEDIYNES 

It is impossible to describe in detail in this chapter all the formidable synthetic efforts that have been dedicated to the total synthesis of natural and artificial enediynes. However, we will try to summarize here the main strategies that have been employed in the preparation of cyclic enediyne rings. In most cases complex bicyclic or polycyclic compounds have been prepared by one of these methodologies. 

the synthetic strategies may be divided into three categories  

Those that form the enediyne moiety first at the acyclic level and then perform a suitable cyclization. 

Those that form the double bond after cyclization. 

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