Synthetic library methods requiring deconvolution

Methods in this category involve the synthesis of a number of peptide mixtures. These mixtures are then screened for a specific biological activity. Once an active mixture is 

Geysen et al. [2] first successfully applied this approach in the multipin system in an on-pin ELISA assay to define a mimotope for a monoclonal antibody directed against a discontinuous epitope on the foot-and-mouth disease virus particle. Later, Houghten et 

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Synthetic Library Methods that Require Deconvolution... 

Synthetic library methods that require deconvolution... 

Any chemically encoded library requires a double orthogonal chemical strategy, or the construction of elaborate tags/linkers on the solid support prior to the synthesis. Even when these are easily prepared and inert, the synthetic scheme becomes more complicated than direct deconvolution methods, where only the library synthesis is required. Sometimes the tag chemistry and the... 

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