Synthesis oxidative methods

We ve already discussed two methods of aldehyde synthesis oxidation of primary alcohols and oxidative cleavage of alkenes. 

In recent years, axially chiral binaphthalene derivatives have emerged as important ligands and chiraUty inducers in organic synthesis. Oxidative coupling of 2-naphthols represents a well estabhshed method for the preparation of binaphthols. The couplings are usually carried out by treating naphthols with more than an equimolar amount of a metal such as Fe(III), Mn(III),... 

Innovative One-Pot Oxidation Method for the Synthesis of Bioproducts from Renewables... 

Benzofurazan oxide has also been prepared by the oxidation of o-nitroaniline with phenyl iodosoacetate.6 Other methods of preparation are given in reference 4. The hypochlorite oxidation method has been used in the synthesis of various substituted benzofurazan oxides.6... 

Therefore, taking into account the potentialities of such lactones as carbohydrate delivery synthons (vide infra), several routes leading to carboxymethyl glycosides (and thus subsequently to the lactones) were investigated, in order to get as many structural variations as possible for widening the scope of their use in synthesis. In addition to the isomaltulose oxidation method (route a), the oxidation of allyl glycosides (route b), and the anomeric alkylation with tert-butylbromoacetate (route c) were studied (Scheme 11). These three methods are detailed in the following sections. 

Two methods are popular in organic synthesis the acid promoted method and the oxidative method. 

The photoelectrochemical behavior of a given photoanode is dependent on its method of synthesis. Various methods, some of which we now briefly consider, such as anodic oxidation, spray pyrolysis, reactive sputtering and vapor deposition are commonly employed to make polycrystalline thin films. 

The advantages of this approach are the opportunity to purify the intermediate S-protected derivatives, the introduction of the disulfide bonds in the early stages of the synthesis/62 and also a one-pot deprotection/resin cleavage/oxidation method/63-65 The main reagents used for this purpose are summarized in Table 2. 

Torii, S. Electroorganic Synthesis Part I, Oxidation Methods and Application, Verlag Chemie, Weinheim 1985... 

The most frequently reported oxidation reaction of isatins is the oxidation with alkaline hydrogen peroxide to give anthranilic acids. This procedure has been both as a proof of structure of isatins and as a method of synthesis of anthranilic acids. The oxidation has been applied to alkyl 8"10 11 23 33>38-40>46 49>50>118halo n.18.35.36-38-40.47.10 .11 . 119,136,240 alkoxy,26,a8 39,47,75.io7,ii8,i36 trifluoromethyl,33,38,137 and nitro8,120,217 isatins. Use of N-substituted isatins led to N-substituted anthranilic acids.66,71,125,158,169,243 In the oxidation of 5-bromo-l-(y-carbethoxypropyl)-7-ethylisatin, 60 was isolated after treatment with ethanol and acid.11 Oxidation of isatin derivatives 61 led, after treatment with diazomethane, to the acridine derivatives 62.67 Application of this oxidation method to 7-hydroxyisatins gave rise to benzoxazo-lones (63).2,41... 

Aldonic and aldaric acids are usually obtained by oxidation methods from the corresponding aldoses, whereas a glycoside is the usual starting material for the synthesis of glycuronic acids, important natural sugars that are constituents of many polysaccharides. 

V D. Filimonov, M. S. Yusubov, Ki-WhanChi, Oxidative Methods in the Synthesis of Vicinal Di- and Poly-Carbonyl Compounds, Russ. Chem. Rev. 1998, 67, 803-826. 

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