Synthesis of Z -l-methoxytetracos-15-en-7-one Rodefeld and W. Tochtermann

Institut fiir Organische Chemie der Universitat Kiel, Olshausenstrafie 40, D-24098 Kiel, Germany. 

In the course of our work on large-ring compounds, we were looking for a new access to cheap precursors for cyclization. In this respect, the sonochemical Barbier reaction of 

96 Scholz, S. Marschall-Weyerstahl, H. Weyerstahl, P. Liebigs Ann. Chem. 1985, 1935-1950. 

97 Uchida, M. Komatsu, M. Morita, S. Kanbe, T. Yamasaki, K. Nakagawa, K. Chem. Pharm. Bull. 1989,37, 958-961. 

Lithium oleate was prepared by neutralization of oleic acid with lithium hydroxide in toluene under reflux and azeotropic removal of water. The solvent was evaporated and the residue washed twice with ether. The remaining traces of solvent were removed in vacuo. The ultrasonic reaction was performed in an ultrasonic laboratory reactor (35 kHz, 4 x 100 W transducers) from Allied Signal ELAC Nautic GmbH, 24118 Kiel, Germany. 

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