Synthesis of the Yeast GPI Anchor

The Ley group s synthesis of a Tryp. brucei GPI showcased a great improvement, as far as efficiency is concerned, over the first report by Ogawa. These improvements came in the form of a more convergent strategy, a more rapid assembly of key polysaccharide building blocks, and also a much shorter synthesis of the inositol building block 28. 

SCHEME 13.5 Synthesis of tetramannosyl donor 38. DBU, l,8-diazabicyclo[5.4.0] undec-7-ene TBDPS, fert-butyldiphenylsilyl. 

SCHEME 13.6 Completion of Schmidt s synthesis of the yeast GPI anchor. CS A, camphor-sulfonic acid. 

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