Synthesis of Staurosporine Aglycon

Abstracted with permission from J. Org. Chem., 1992,57, 2105 1992 American Chemical Society 

Abstracted with permission from Angrtv. Chan., Int Ed. Engl., 1995,34, 2683 1995 VCH Verlaggesellschatt 

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Oxidative homocoupling of aromatic and heteroaromatic rings proceeds with Pd(OAc)2 in AcOH. Biphenyl (165) is prepared by the oxidative coupling of benzene [104,105], The reaction is accelerated by the addition of perchloric acid. Biphenyl-tetracarboxylic acid (169), used for polyimide synthesis, is produced from dimethyl phthalate (168) commercially [106], Intramolecular coupling of the indole rings 170 is useful for the synthesis of staurosporine aglycone 171 [107]. 

Rajeshwaran GG, Mohanakrishnan AK. S3mthetic studies on indolocarbazoles Total synthesis of staurosporine aglycon. Qrg. Lett. 2011 13 (6) 1418-1421. 

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