Synthesis of Polyketides-Focus on Macrolides

Institute for Organic Chemistry and Center of Biomolecular Drug Research (BMWZ), Leibniz Universitdt Hannover, Hannover, Germany and Helmholtz Center for Infection Research (HZI), Hannover, Germany 

FIGURE 2.1 First three modules of the biosynthesis of soraphen. 

SCHEME 2.96 Comparison of biosynthesis and chemical synthesis of polyketides. 

In this chapter, we will cover both aspects, the aldol strategy and the selective reduction of carbonyl groups in the context of 1,3-diol formation. Additionally, nonaldol approaches will be covered as weU. 

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