Synthesis of Plasmodium falciparum GPI Anchor

Phospholipidation of the 1-alcohol 86 took place using phosphoramidite 87 followed by oxidation with mCPBA. Hydrogenation, catalyzed by Pd, reduced the azido group and removed the Bn protection to provide the target GPI 89. 

SCHEME 13.12 Completion of Fraser-Reid s synthesis of the Plasmodium falciparum GPI 

SCHEME 13.13 Synthesis of the key tetramannosyl donor 93 and pseudodisaccharide acceptor 96 for the assembly of the Plasmodium falciparum GPI anchor. 

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