Synthesis of PGF

The self-complexed catalyst of ALB and a base was also saccessftilly applied to the above-mentioned three-component coupling reaction of an enone, an aldehyde, and a malonate. A catalytic asymmetric synthesis of 1 l-deoxy-PGFj was achieved by utilizing this reaction as the first key step (Scheme 8D.14) [31], Furthermore, a potential key intermediate 25 for the synthesis of PGF q was synthesized in relatively high yield with extremely high enantioselec-tivity (97%) by the kinetic resolution of the three-component coupling between racemic enone 24, aldehyde 22, and methyl dibenzylmalonate 23 [31]. 

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