Synthesis of organic molecules

G. Van Binst, ed.. Design and Synthesis of Organic Molecules Rased on Molecular Recognition, Springer, New York, 1986. 

Estep KG, Neipp CE, Stramiello LM, Stephens A, Mavis D, Allen MP. Indole resin A versatile new support for the solid-phase synthesis of organic molecules. J Org Chem 1998 63 5300-5301. 

A development of the last two decades is the use of Wacker activation for intramolecular attack of nucleophiles to alkenes in the synthesis of organic molecules [9], In most examples, the nucleophilic attack is intramolecular, as the rates of intermolecular reactions are very low. The reaction has been applied in a large variety of organic syntheses and is usually referred to as Wacker (type) activation of alkene (or alkynes). If oxygen is the nucleophile, it is called oxypalladation [10], Figure 15.4 shows an example. During these reactions the palladium catalyst is often also a good isomerisation catalyst, which leads to the formation of several isomers. 

In marked contrast to those of cyclopropanes, the addition reactions of cyclobutanes usually require drastic conditions and activating substituents. Notwithstanding these shortcomings, the cleavage of cyclobutanes by addition reactions has been widely employed in the synthesis of organic molecules of moderate complexity. In this section, electrophilic addition, as well as nucleophilic addition, of cyclobutanc derivatives are reviewed with the aim of demonstrating their synthetic profile. 

The synthesis of organic molecules containing multiple redox active chromo-phores is of particular interest due to their importance not only for the preparation of materials with novel properties but also as multi-electron redox catalysis88. Hexaphenyl benzene and tetraphenylmethane have been reported as plat-... 

Porcheddu, A., Ruda, G.F., Sega, A. and Taddei, M., Anew, rapid, general procedure for the synthesis of organic molecules supported on methoxy-polyethylene glycol (MeOPEG) under microwave irradiation conditions, Eur. J. Org. Chem., 2003, 907-912. 

Stanley L. Miller The Prebiotic Synthesis of Organic Molecules... 

A.19 Design and Synthesis of Organic Molecules Based on Molecular Recognition, (Ed. G. van Binst), Springer, Heidelberg, 1986. 

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