Synthesis of Fused Polyheterocycles

Nuevamine 179 is an alkaloid that was isolated from Berberis darwinii, and it is the first tetrahydroisoindolo[l,2-fl]isoquinoline amide found in natural sources [51]. An Ugi 

SCHEME 6.19 Three-component aza-Diels-Alder reaction to create indoles derivatives 140. Catalyst (5)-139 was used. 

FIGURE 6.6 Indoles 140k-m, which were tested against different cell lines. 

SCHEME 6.20 Three-component tandem reaction to synthesize acyclic prodncts— indole derivatives 146—with three contiguons 

FIGURE 6.7 Natural products 149-156, containing fused heterocycles. 

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