Berberis darwinii

The reaction of oxyberberine (58) and berberine (15) with dichlorocarbene has been previously reviewed (11). An interesting product was the keto lactam 189, which was obtained from 58 via the adduct 188 (Scheme 34) (105). This product was later isolated from Berberis darwinii and named magallanesine (106) however, this alkaloid has since been shown to be an artifact (107). 

Dihydrorugosinone (79) Berberis darwinii Hook. 172-174 (0.00002), 220- 223 Berberis actinacantha... 

Berberis darwinii Hook, afforded (-t-)-l-O-methylchitraline (263), C37H40N2O6, amorphous, [a] 5 +29° (c 0.4, MeOH), previously obtained (28) as a rearrangement product of patagonine (262) (557). 

The isoindolobenzazocine alkaloid magallanesine T371) has been isolated from Berberis darwinii (Valencia et al., Tetra-... 

Alkaloids of tnis sub-group have been isolated from the following Berberis darwinii protopine... 

Dichlorovinylamide (81) is a key intermediate used in the synthesis of the alkaloid lennoxamine which is prepared via coupling of amine 79 and aryl acid 80 using DEPC.31 Lennoxamine was isolated from the Chilean barberries Berberis darwinii and belongs to a group of isoindolobenzazepine alkaloids. 

Valencia, E., Weiss, I., Shamma, M., Urzua, A., and Fajardo, V (1984) Dihydrorugosme, a pseudobenzylisoquinoline alkaloid from Berberis darwinii aad Berberis actinacantha. J. Nat. Prod. 47, 1050,1051. 

Nuevamine 179 is an alkaloid that was isolated from Berberis darwinii, and it is the first tetrahydroisoindolo[l,2-fl]isoquinoline amide found in natural sources [51]. An Ugi... 

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