Synthesis of Enantiomerically Pure Noncarbohydrate Compounds

Williams, N R, Davison, B E, Perrier, R J, Fumeaux, R H, Synthesis of enantiomerically pure noncarbohydrate compounds, Carbohydr. Chem., 17, 244-255, 1985. 

Chapter 24 Synthesis of Enantiomerically Pure Noncarbohydrate Compounds... 

Sugar derivatives that contain double bonds have been developed and used so extensively that they almost certainly constitute the most versatile category of carbohydrate compounds available for use in synthesis. They may be applied both in the synthesis of complex members of the family and of a myriad enantiomerically pure noncarbohydrate compounds—notably, many of interest in medicinal chemistry. Furthermore, some unsaturated sugar derivatives have themselves been found to possess important therapeutic properties. For example, the unnatural L-nucleoside 1 inhibits reverse transcriptase and shows potent and selective anti-AIDS activity,1 and the unsaturated neuraminic acid analogue 2 is the sialidase-inhibitory... 

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