Synthesis of Compound Libraries with High Scaffold Diversity

3 Synthesis of Compound Libraries with High Scaffold Diversity 

The folding pathway approach uses common reaction conditions to transform a range of substrates into products with alternative molecular scaffolds. The substrates are encoded to fold into the alternative scaffolds through strategically placed appending groups (sometimes known as c-elements ). This strategy leads to scaffold diversification under substrate control. 

The branching pathway strategy involves the conversion of common precursors into a range of distinct molecular scaifolds through careful choice of the 

3 Introducing Scaffold Diversity by Combining Building Blocks the Build-Couple-Pair Strategy 

The build-couple-pair is an extremely powerful and flexible approach for preparing small molecule libraries based on a diverse range of scaffolds. The approach is highly general, and many different reactions have been used to connect ( couple ) building blocks. Variants of the Ugi multi-component reaction are, however, still over-represented amongst the reactions that have been used to connect building blocks. 

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