Synthesis of 3a-Acetamino-23,24-bisnor-5a-cholane

Buchner funnel with filter paper (Advantec No. 2) 

One 50 mL round-bottomed flask with a magnetic bar Magnetic stirrer plate 

Medium pressure liquid chromatography (MPLC) Lobar Li Chroprep Si 60 (40-63 pm) column (E.M. Merck) 

A mixture of 1 (100 mg, 0.2 mmol) and ammonium trifluoromethanesulfonate (377 mg, 2.2 mmol) in THE (10 mL) was reacted with NaBH(OEh)3 (2 equiv) at room temperature under an argon atmosphere. The reaction was monitored by TLC analysis. After the reaction was complete, the solvent was removed by a rotary evaporator, the mixture extracted with ethyl acetate, dried over anhydrous Na2S04, and concentrated. 

---