Synthesis in solid state

J.C. Schn and M. Jansen, First Step towards Planning of Synthesis in Solid-state Chemistry. Angew. Chem., Int. Ed. Engl., 1996, 35, 1286-1304. 

The earlier belief that no reaction is possible without the use of a solvent is no more valid. It has been found that a large number of reactions occur in solid state without the solvent. In fact in a number of cases, such reactions occur more efficiently and with more selectivity compared to reactions carried out in solvents. Such reactions are simple to handle, reduce pollution, comparatively cheaper to operate and are especially important in industry. There is some literature available on different aspects of organic synthesis in solid state. It is believed that solvent-free organic synthesis and transformations are industrially useful and largely green. 

Organic Synthesis in Solid State 191 13.2.2 Hydrohalogenation (addition of HBr)... 

Organic Synthesis in Solid State 209 13.2.16.3 Synthesis of Azomethines... 

Organic Synthesis in Solid State 227 13.3.14 Synthesis of Thiadiazepines... 

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