Synthesis continuous serial combinatorial

The examples shown in this review article demonstrate that a variety of methods for polymer synthesis have been developed in flow microreactors. Continuous flow synthesis enables serial combinatorial synthesis, in which a variety of polymers can be synthesized in a sequential way using a single flow reactor with a flow switch. Space integration, which enables the synthesis of structurally well-defined polymers without isolating living polymer ends, also enhances the power and speed of polymer synthesis. Because several test plants for continuous production have already been built, there is no doubt that flow microreactors can contribute to polymer production in industry. 

Figure 7.6 Continuous serial combinatorial synthesis using the cation flow system.

OS 30] [R 30] [P 22] By simple flow switching, serial combinatorial synthesis for creating a cation pool from diverse carbamates and silyl enol ethers was accomplished (Figure 4.46) [66, 67]. The conversions and selectivities were comparable to continuous processing using three feed streams only (see Conversion/yield/selec-tivity, above). 

The serial method based on continuous flow synthesis by simple flow switching is useful. Although the parallel method needs to use many reactors in parallel, the serial method needs to use only one flow reactor. Different substrates and/or reagents are fed sequentially to the inlets of the flow reactor and different products are produced sequentially at the outlet of the reactor. CtMitinuous operation of this system leads to synthesis of many different compounds in a combinatorial manner. 

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