Synonymous and nonsynonymous substitution rates are correlated with protein structure

Synonymous and nonsynonymous substitution rates are correlated with protein structure 

The relationships between nucleotide substitution rates in eoding sequences and predicted (on the basis of a consensus of flve methods) secondary structures of encoded proteins were investigated by Chiusano et al. (1999) on 34 alignments, each one of which comprised sequences belonging to at least four mammalian orders. The rates of synonymous and nonsynonymous substitutions were found not to be signifleantly diflerent in aperiodic and o-helix, whereas they were significantly lower in /3-strand, the most hydrophobic structure, compared to the other two structures (see Table 10.1). Expeetedly, in all cases nonsynonymous rates were lower than synonymous rates. 

Mean values and standard deviation (sd) of synonymous (SYN) and nonsynonymous (NSY) substitution rates in protein structures  

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Synonymous and nonsynonymous substitution rates are correlated with protein structure an intragenic analysis of the Leishmania GP63 genes... 

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