Syndrome disconnection

GeschwindN (1975) The apraxias neural mechanisms of disorders of learned movement. Am Sci 63 188-195 Geschwind DH, Iacoboni M, Mega MS et al (1995) Alien hand syndrome interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum. Neurology 45 802-808... 

Taking this information together with the imaging data (MRI-CBV) maps demonstrating a hypermetabolic phase in very young AD and Down-syndrome mice and a later age-dependent hypometabolism (Moreno et al., 2006, 2007), it seems plausible to propose that this series of events leads to a biphasic neuronal disconnection syndrome, with an initial hyperactive state followed by subsequent synaptic failure phase (Fig. 12). 

Geschwind, D. H. Levitt, P. (2007). Autism spectrum disorders developmental disconnection syndromes. Curr. Opin. Neurobiol. 17 103—11. 

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