Synaptotagmin neurotoxin

Li JY, Jahn R, Dahlstrom A (1994) Synaptotagmin I is present mainly in autonomic and sensory neurons of the rat peripheral nervous system. Neuroscience 63 837-50 Li L, Binz T, Niemann H, Singh BR (2000) Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain. Biochemistry 39 2399-2405 Ludlow CL, Hallett M, Rhew K, Cole R, Shimizu T et al. (1992) Therapeutic use of type F botulinum toxin. N Engl J Med 326 349-50... 

Niemann H (1991) Molecular biology of clostridial neurotoxins. In Alouf J, Freer J (eds) A source-book of bacterial protein toxins. Academic Press, London, pp 303 18 Nishiki T, Tokuyama Y, Kamata Y, Nemoto Y, Yoshida A et al. (1996) The high-affinity binding of Clostridium botulinum type b neurotoxin to synaptotagmin ii associated with gangliosides gtlb/gdla. FEBS Lett 378 253-7... 

Yowler BC, Kensinger RD, Schengrund C (2002) Botulinum neurotoxin a activity is dependent upon the presence of spedfic gangliosides in neuroblastoma cells expressing synaptotagmin I. J Biol Chem 277 32815-19... 

Nishiki, T., Tokuyama, Y., Kamata, Y., Nemoto, Y., Yoshida, A., Sato, K., Sekiguchi, M., Takahashi, M., Kozaki, S. (1996). The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GTlb/ GDI a. FEBS Lett. 378 253-7. 

Kohda, T., Ihara, H., Seto, Y., and Tsutsuki, H. 2007. Differential contribution of the residues in C-terminal half of the heavy chain of botulinum neurotoxin type B to its binding to the ganglioside GT lb and the synaptotagmin 2/GTlb complex. Microb. Pathog. 42 72-79. 

Li, L. and Singh, B.R., Isolation of synaptotagmin as a receptor for types A and E botulinum neurotoxin and analysis of their comparative binding using a new microtiter plate assay, J. Nat. Toxins, 7, 215, 1998. 

Dong, M., Richards, D.A., Goodnough, M.C., et al, 2003. Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. J. Cell Biol. 162, 1293-1303. 

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