Synaptic association with dysbindin

Dysbdindin-1 may also affect synaptic vesicle fusion via interaction with its known or candidate binding partners sec8, snapin, and syntabulin. Sec8, like dysbindin-1 A and -IB, is associated with presynaptic membranes (Hsu et al., 1996 Vik-mo et al., 2003). It is a member of the exocyst complex... 

As noted earlier (see O Section 2.2.63.i), dysbindin-lB in human synapses is almost exclusively associated with synaptic vesicles. Consequently, our recent finding that dysbindin-lB is reduced in the hippocampal formation of schizophrenia cases confirms our previous quantitative immunohistochemi-cal finding that reduced dysbindin-1 occurs in glutamatergic presynaptic fields of associational and... 

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