Synapse glial cells, role

The disclosure of this active role of glia led to the model of the tripartite synapse (Araque et al, 1999 Bezzi and Volterra, 2001), where, besides the important tasks pursued by pre- and postsynaptic neuronal elements, a pivotal role in regulating synaptic function, strength, and plasticity is played by the glial cells surrounding the above-mentioned structures. 

Unspecific cholinesterase (BuChE) has been found in the glial cells surrounding the synapse. Its physiological role is not clear. It is possible that BuChE prevoits the leakage of unhydrolysed ACh out of the synapse and the penetration of ACh and ACh-like substances into the synapse. 

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