Sweating zonisamide

Children appear to be at an increased risk for zonisamide-associated oligohydrosis and hyperthermia. Closely monitor patients, especially children, treated with zonisamide for evidence of decreased sweating and increased body temperature,... 

A 10-year-old boy who had taken zonisamide for about 9 months noticed that he had a dry skin and that he seldom sweated. His zonisamide blood concentration was very high. He discontinued zonisamide and became able to sweat. 

In 16 patients taking zonisamide, acetylcholine stimulation testing after about 1 month was normal in four cases and reduced in 12 (12). There was reduced sweating in... 

Children receiving zonisamide should be monitored closely for evidence of reduced sweating and increased body temperature, especially in warm or hot weather and when taking other drugs that predispose to this (carbonic anhydrase inhibitors, anticholinergic drugs, topiramate). 

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