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SV40 viruses, cancer caused

DNA viruses. Some DNA viruses also cause human cancer, but by different mechanisms. Three DNA tumor virus families, SV40, papillomavirus, and adenovirus, encode proteins that inactivate pRb and p53. By interfering with the Gl/S checkpoint, these oncoproteins increase the probability that mutations in oncogenes and tumor suppressor genes will be incorporated into the genome of infected cells, thereby increasing the probability of transformation. The Epstein-Barr virus encodes a Bcl-2 protein that restricts apoptosis of the infected cell. [Pg.335]

S th l ridization thus proved ituid f ofyoma virus DNA integrated with the host genome before it caused cancer Similar results wei obtained>with SV40 and other viruses which caused cancer and proved that they also integrated like polyoma before they caused tiansformation... [Pg.478]

See other pages where SV40 viruses, cancer caused is mentioned: [Pg.58]    [Pg.564]    [Pg.105]    [Pg.397]    [Pg.421]    [Pg.244]    [Pg.1550]    [Pg.1650]    [Pg.299]    [Pg.2882]    [Pg.98]    [Pg.637]    [Pg.737]    [Pg.616]    [Pg.716]    [Pg.16]   


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