Suzuki reaction hydroboration-intramolecular

Intramolecular Suzuki reactions have been done by hydroboration followed by... 

Similarly, while exploring a route toward the synthesis of strychnine, Bodwell and Li reported hydroboration of i f-[2-(l-allyl-17/-indol-3-yl)ethyl]-6-iodopyridazin-3-amine 184 followed by intramolecular Suzuki reaction (Scheme 45) <2002AGE3261>. 

Bauer and Maier synthesized the benzolactone 538, which has the core structure of salicylihalamide A, using intramolecular Suzuki reaction.228 Hydrobora-tion of the alkenyl iodide-alkene 537 with 9-BBN and subsequent Suzuki reaction in the presence of a palladium catalyst gave the macrolactone 538 in 48% yield (Scheme 160). The hydroboration proceeded with high diastereoselectivity. 

An enantioselective total synthesis of (+)-phomactin A (181) has been recently reported by Halcomb using intramolecular Suzuki coupling of a B-alkyl-9-BBN derivative to prepare the macrocycle in the final step [162,163], Thus, a regioselective hydroboration of the terminal olefin in the precursor 182 gave an internal alkyl-borane that was cyclized using modification of Johnson s conditions [164], The reaction illustrates the mildness of the Suzuki reaction since the coupling was carried out in the presence of the sensitive dihydrofuran ring (Scheme 3.95). 

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