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Suzuki cross-coupling reactions Buchwald-Hartwig amination

The generally accepted catalytic cycle for the Buchwald-Hartwig amination mirrors that of other palladium catalyzed cross-coupling reactions.10 11 irThere is an oxidative addition (A to B), followed by an exchange on palladium (B to C), and finally a reductive elimination (C to D and A). The main difference involves the exchange step. In a Suzuki, or Stille, reaction this step proceeds through a discrete transmetallation event, whereas... [Pg.566]

Arylation of a wide range of NH/OH/SH substrates by oxidative cross-coupling with boronic acids in the presence of catalytic cupric acetate and either triethyl-amine or pyridine at room temperature in air. The reaction works for amides, amines, anilines, azides, hydantoins, hydrazines, imides, imines, nitroso, pyrazi-nones, pyridones, purines, pyrimidines, sulfonamides, sulfinates, sulfoximines, ureas, alcohols, phenols, and thiols. It is also the mildest method for NIO-vinylation. The boronic acids can be replaced with siloxanes or starmanes. The mild condition of this reaction is an advantage over Buchwald-Hartwig s Pd-catalyzed cross-coupling. The Chan-Lam C-X bond cross-coupling reaction is complementary to Suzuki-Miyaura s C-C bond cross-coupling reaction. [Pg.102]


See other pages where Suzuki cross-coupling reactions Buchwald-Hartwig amination is mentioned: [Pg.56]    [Pg.46]    [Pg.771]    [Pg.581]    [Pg.125]    [Pg.89]    [Pg.566]    [Pg.205]   
See also in sourсe #XX -- [ Pg.573 ]




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Amines coupling

Amines coupling reactions

Buchwald coupling reaction

Buchwald cross-coupling

Buchwald-Hartwig

Buchwald-Hartwig amination

Buchwald-Hartwig aminations

Buchwald-Hartwig couplings

Buchwald—Hartwig amine

Buchwald—Hartwig cross-coupling

Cross Buchwald-Hartwig aminations

Cross-coupling reactions Suzuki couplings

Hartwig

Suzuki coupling

Suzuki cross-coupling

Suzuki cross-coupling reaction

Suzuki reaction

Suzuki reaction reactions

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