Suxamethonium, postoperative myalgia

Statins, see HMG Co-A reductase inhibitors Steroids, see Glucocorticoids Stimulants, in ADHD, 31.4 Sugammadex, 32.275 Sulfonamide derivatives, hypersensitivity reactions, 30.252 Sumatriptan, 17.171 Suprofen, nephrotoxicity, 12.88 Suramin, patients with prostate cancer, 20.283 Surgam, gastric reactions, 12.89 Suxamethonium, postoperative myalgia,... 

Other measures, much disputed, include the prior injection of diazepam (58,59), procaine or hdocaine (57), vitamin C, suxamethonium itself (10 mg), and aspirin (51,52). The combined use of atracurium 0.05 mg/kg and hdocaine 1.5 mg/kg reduced the incidence of postoperative myalgia to 5% compared with 75% in controls (57). Thiopental, injected immediately beforehand, is also said to have some effect, as is giving the suxamethonium slowly. 

The problem of suxamethonium-associated postoperative myalgia has been reviewed (214). Key statements are ... 

Manataki AD, Arnaoutoglou HM, Tefa LK, Glatzounis GK, Papadopoulos GS. Continuous propofol administration for suxamethonium-induced postoperative myalgia. Anaesthesia 1999 54(5) 419-22. 

Thiopental can reduce muscle fascicula-tion associated with suxamethonium [3 ]. In 300 ASA I and n patients, who were randomized to suxamethonium immediately after thiopental or 30 seconds later, the onset of fasciculation was earher in the former and the duration of fasciculation was shorter in addition, there was moderate to severe fasciculation in the latter. The relation between fasciculations and postoperative myalgia has not been well defined. The authors did not comment on the incidence and severity of myalgia after surgery. 

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