Survey of SDG Programs

There may be few publications on SDG, but the approaches that have appeared are clever, diverse, and largely complementary. Future solutions may well be fashioned to incorporate the best attributes of existing programs. Salient aspects of a given SDG implementation are as follows  

Selective redesign capability. This subject has not been broached in the literature, although it is apparent that a few commercial drawing packages support it. (ChemWindow, ChemDraw, and ChemSketch do ISIS/Draw 2.1 does not.) 

Fragment interpositioning. Most programs have little or no capability to separate fragments (see prior section on Fragment Interpositioning). 

A brief history of the development of SDG is warranted, and in Table 34,7,11,12,14,18,21,22,32-40 present a chronological list of the SDG publications and some of the prominent programs. A more in-depth discussion of the attributes and distinguishing features of each method follows. Where informative, representative results from various programs are included. 

7 1993 CAMEO/Helson (Purdue University) V Synthesis StrEd 

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The architectures of different SDG implementations naturally vary, but Figure 13 contains a good one that is representative of the majority and is used in the sections to follow. Differences in algorithms (notably Carhart s ) are taken up later in the section on Survey of SDG Programs. 

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