Surfactants nasal formulations

For the consumer, the sensation of a cold puff into a nostril, with resulting irritation through surfactants and propellants, is not appreciated. A further disadvantage of pressurized systems is the power of the impact of the drug formulation on the nasal mucosa. The deposition occurs on a relatively limited area and therefore, the drug is not distributed evenly over the mucosa. Studies recommend that two doses be administered at different angles into the nostril in order to cover a sufficient area of the mucosa. It is recommended that physicians instruct their patients on the proper use of prescribed nasal aerosols. 

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