Surfactant polypeptide functionalized

Fig. 4.19 Preparation of a protein-like structure in an inorganic mesostructured framework (Proteosilica) as a transparent film using polypeptide-functionalized surfactants.

Proteins SP-B and SP-C are small extremely hydrophobic polypeptides consisting of 79 and 35 amino acid residues, respectively." 0 Aliphatic branched amino acids constitute 23 of the 35 residues of the C-terminal part of protein C, which is also palmitoylated on two cysteine residues. SP-B is formed from a large 381-residue precursor. The mature protein contains seven cysteines and disulfide bridges. Both proteins have major effects on the properties of the surfactant mixture. They promote rapid reorganization of lipid layers, an important consideration for the functioning of the surfactant. Infants lacking SP-B suffer severe respiratory failure with high mortality.6... 

Vitamin B6 enzyme models that can catalyze five types of reactions - transamination, racemization, decarboxylation, P-elimination and replacement, and aldolase-type reactions - have been reviewed. There are also five approaches to construct the vitamin B6 enzyme models (i) vitamin B6 augmented with basic or chiral auxiliary functional groups (ii) vitamin B6 having an artificial binding site (iii) vitamin B6-surfactant systems (iv) vitamin B6-polypeptide systems (v) polymeric and dendrimeric vitamin B6 systems. These model systems show rate enhancement and some selectivity in vitamin B6-dependent reactions, but they are still primitive compared with the real enzymes. We expect to see improved reaction rates and selectivities in future generations of vitamin B6 enzyme models. An additional goal, which has not received ade-... 

In an analogous approach to those discussed above, Klok, Mezzenga, and co workers prepared bioinspired complexes by ionic complexation of hyperbranched polypeptides and surfactants [113] that lead to columnar hexagonal or lamellar mesophases, as a function of surfactant alkyl chain length [113]. 

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