Surface between hydrogen-bonding

Water has strong interactions with paper wood, or cloth because the molecules in their surfaces form hydrogen bonds that can replace some of the hydrogen bonds between water molecules. As a result, water maximizes its contact with these materials by spreading over them in other words, water wets them. We now see that water is wet because of the hydrogen bonds its molecules can form. 

Several papers have also been published in which a correlation has been sought between permeation across Caco-2 cells and physicochemical properties of the compounds. The review article by Ekins et al. (2000) discusses several studies to predict Caco-2 cell permeation. Correlations have been found with polar surface area, hydrogen bond descriptors, VolSurf, and other parameters. Van de Waterbeemd et al. (2001a) also discuss models for predicting oral absorption of compounds, including the use of Caco-2 cell lines. This paper also provides much useful information on the optimization of pharmacokinetic parameters in drug development. 

IR spectroscopy is one of the useful methods to study the hydrogen-bonded pairing between the bases. The measurements are generally carried out in aptotic solvents and the hydrogen-bonded pairing is discussed from the shift of v(NH) and v(C=0). Unfortunately, this approach cannot be used for the studies at the solid/water interface, because both adenine moiety of the SAM and thymidine are hydrated in water and the distinction between hydrogen bonds between the complementary base pair and those between the bases and water is practically impossible from the v(NH) and v(C=0) modes only. The interaction between the surface-confined 6-amino-8-purinethiol and thymidine was discussed from the potential dependence of the band intensities of the v(OH) mode of water and some modes of adenine moiety in this study. 

Relation Between Hydrogen-Bonding Activity and Potential Surface... 

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