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Suprachiasmatic nucleus actions

Ramelteon (Rozerem). Recently approved by the FDA for treatment of insomnia in the US, ramelteon acts via a completely novel mechanism of action, that is, stimulating so-called melatonin Ti and T2 receptors in the brain s suprachiasmatic nucleus (SCN). The SCN is regarded as the body s master clock that regulates the sleep-wake cycle and other circadian rhythms. The effects of ramelteon in some respects mimic those of melatonin. Ramelteon, in clinical trials, administered at bedtime doses of 8 mg, outperformed placebo with respect to several indices of sleep disturbance (see Table 9.4). [Pg.273]

Maywood ES, Okamura H, Hastings MH 2002 Opposing actions of neuropeptide Y and light on the expression of circadian clock genes in the mouse suprachiasmatic nucleus. Eur J Neurosci 15 216-220... [Pg.217]

See other pages where Suprachiasmatic nucleus actions is mentioned: [Pg.234]    [Pg.267]    [Pg.41]    [Pg.250]    [Pg.81]    [Pg.143]    [Pg.478]    [Pg.479]    [Pg.483]    [Pg.75]    [Pg.227]   


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Suprachiasmatic nucleus

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