Supported reagents applications

S. V. Ley, l.R. Baxendale, G. Brusotti, M. Caldarelli, A. Massi and M. Nesi, Solid-supported Reagents for Multi-step Organic Synthesis Preparation and Application, II Farmaco 57 321-330 2002. 

S. Bhattacharyya, Polymer-supported reagents and catalysts Recent advances in synthetic applications. Comb Chem High Throughput Screening 3 65-92 2000. 

In this section, we will review the application of the combination of polymer-supported reagents and/or scavengers with microwave irradiation to the syn-... 

The quest for a solvent-free deprotection procedure has led to the use of relatively benign reagent, ammonium persulfate on silica, for regeneration of carbonyl compounds (Scheme 6.10) [48]. Neat oximes are simply mixed with solid supported reagent and the contents are irradiated in a MW oven to regenerate free aldehydes or ketones in a process that is applicable to both, aldoximes and ketoximes. The critical role of surface needs to be emphasized since the same reagent supported on clay surface delivers predominantly the Beckmann rearrangement products, the amides [49]. 

Baxendale IR, Ley SV (2000) Polymer-supported reagents for multi-step organic synthesis application to the synthesis of sildenafil. Bioorg Med Chem Lett 10 1983-1986... 

Beilina F, Carpita A, Rossi R (2004) Palladium catalysts for the Suzuki Crosscoupling reaction an overview of recent advances. Synthesis 2419-2440 Bhattacharyya SJ (2000) Polymer-supported reagents and catalysts recent advances in synthetic applications. Comb Chem High Throughput Screening 3 65-92... 

Jamieson C, Congreave MS, Emiabata-Smith DF, Ley SV, Scicinski J (2002) application of ReactArray robotics and design of experiments techniques in optimisation of supported reagent chemistry. J Org Proc Res Dev 6 823-825... 

Ley S V, Baxendale IR, Brusotti G, Caldarelli M, Massi A (2002b) Solid-supported reagents for multi-step organic synthesis preparation and application. Farmaco 57 321-330... 

Thompson LA (2000) Recent applications of polymer-supported reagents and scavengers in combinatorial, parallel, or multistep synthesis. Curr Opio Chem 4 324-337... 

Supported reagents have found application in many areas of synthesis including the construction of small peptides, the traditional foundation stone of solid phase synthesis. For example a recent paper describes the preparation of dipeptide p-nitroanilide and phosphonate libraries by supported carbodiimide coupling and scavenger purification (Scheme 2.52) [79]. 

In the 1970s and 1980s, however, it was believed that the key to wider use of solid-phase supported reagents and catalysts is their adoption in industry for fine chemical and pharmaceutical manufacturing on a large scale. In fact, this restricted view hampered their wide use [7]. The dramatic developments in the need for compound library preparation in pharmaceutical and agrochemical industries have finally removed functionalized supports from their academic corner and helped reinvent them for industrial purposes and applications. 

Advances in the Applications of Polymer-Supported Reagents for Organic Synthesis... 

---