Superoxide dismutases controls

Figure 4.8 Reduction of Na/K ATPase activity in isoiated guinea-pig hearts subjected to ischaemia/reperfusion and its prevention by various agents control non-ischaemic hearts (Nl) guinea-pig hearts subjected to global ischaemia for 2 h and subsequently reperfused for 1 h (IR). In other preparations, superoxide dismutase (SOD) 100 U/ml, catalase (CAT) 150 U/ml, dimethylsulphoxide (DMS) 50 mu, histidine (HIS) 10 mu, vitamin E (TOC)...

Collier et al. (1990) extended their studies relating to oxidative stress and diabetes by demonstrating that the levels of several free-radical scavengers (red cell superoxide dismutase, plasma thiols) were significantly reduced in 22 type 2 diabetic patients (mean age 53 years) in comparison with 15 control subjects (mean age 51 years). No significant diflFerences in red cell lysate thiols or... 

The roles of Na(I), K(I), and Ca(II) in neurochemistry are well known, but it is also apparent that Fe and Cu enzymes can control neurotransmitter biosynthetic pathways, and there are millimolar levels of Zn2+ in the hippocampus during neurotransmission (487, 488). Moreover, Mn is abundant in brain enzymes such glutamine synthase and superoxide dismutase. 

Copper is a component of many enzymes including amine oxidase, lysyl oxidase, ferroxidase, cytochrome oxidase, dopamine P-hydroxylase, superoxide dismutase and tyrosinase. This latter enzyme is present in melanocytes and is important in formation of melanin controlling the colour of skin, hair and eyes. Deficiency of tyrosinase in skin leads to albinism. Cu " ion plays an important role in collagen formation. 

Just as the erythrocyte provided the first homogeneous superoxide dismutase the granulocyte has been the exemplar of the cell which forms O in a controlled and apparently purposive manner. In the years following the demonstration by Babior et al. that polymorphonuclear neutrophils (PMNs) formed O when stimulated with... 

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