Supercritical fluid chromatography current limitations

Infrared spectroscopy is probably the most widespread analytical spectroscopic technique for identification and characterization of organic compounds. Because of this identification capability infrared spectroscopy is desirable as a detection technique for chromatographic separations. With the advent of Fourier transform infrared spectroscopy/ the speed and sensitivity of infrared detection is greatly enhanced making such applications feasible. FT-IR detection has been widely accepted as a detector for gas chromatography (GC/FT-IR) (1) and has been applied with limited success to liquid chromatography (LC/FT-IR) (2)/ and more recently to supercritical fluid chromatography (SFC/FT-IR) (3). The recent review articles cited here provide excellent introduction and references to current state-of-the-art in these areas. 

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