Supercritical carbon dioxide heterocyclic synthesis

Oxazolidinones are useful heterocyclic compounds in organic synthesis. They have a wide range of applications in asymmetric syntheses as chiral reagents and, since they have good antibacterial properties, in medicinal chemistry [53]. Oxazolidinones can be synthesized in traditional solvents such as acetonitrile [54] or DMF [5 5], but it is more environmentally friendly to use scC02 [56]. In the reaction an internal propargyl alcohol, carbon dioxide, and a primary amine participate in a cycloaddition reaction under supercritical conditions to give 4-alkylene-l,3-oxazoli-din-2-ones (Equation 4.30). 

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