Summation of Current Concepts

To obtain a total perspective on glomerular disease, first it is important to recognize that progressive glomerular disease is accompanied by persistent proteinuria. Renal function begins to deteriorate as glomerulosclerosis develops. 

Role of Growth Factors and Cytokines in Renal Disease 

The release of some of these mediators attracts inflammatory cells such as macrophages, neutrophils, and T cells to the renal parenchyma, in addition to platelets. The consequence of infiltration of the renal parenchyma by these inflammatory cells and platelets is the activation of glomerular cells to produce mitogenic or growth factors. 

There are other causes of glomerular injury. They range from deposition of compounds with biological activity, such as immunoglobulins, cryoglobulins, 

Current Interest in the Measurement of Glomerular Filtration Rate 

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