Summary of stationary phases used in HPLC

The intention of this book is to focus mainly on applications of techniques to pharmaceutical analysis. Detailed discussions of stationary phases and detectors can be found elsewhere.Table 12.1 summarises some of the stationary phases which 

In recent years polymeric phases have become available for certain specialist applications the surface chemistries of these phases are similar to those of the silica gel-based phases. Advantages of the polymeric phases are stability to extremes of pH and the lack of secondary interactions of analytes with uncapped silanol groups. Disadvantages include expense and a tendency to swell when in contact with lipophilic mobile phases, which can destroy them. Such phases are best used with predominantly aqueous-based mobile phases. 

Octyl silane and butyl silane silica gels 

Aminopropyl silica gel Cyanopropyl silica gel Strong cation exchanger (SCX) 

Useful for slightly more selective analyses of compounds containing large numbers of aromatic rings, e.g. propranolol and naproxen, where some additional interactions can occur with the phenyl groups on the stationary phase. These interactions are, however, very subtle 

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