Summary of atypical antipsychotic dosing in acute mania

Drug Key features Starting dose Dose titration Target dose 

Olanzapine Moderate weight gain, somnolence 10-15 5 mg/day increments 5-20 

Risperidone Mild weight gain, EPS at high doses 2-3 1 mg/day increments 1-6 

Aripiprazole Akathisia, typically weight neutral 15-30 15 mg increments 30 

Quetiapine Sedation, mild weight gain, orthostatic hypotension 100 50-100 mg/day increments 600 

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TABLE 5-4. Summary of atypical antipsychotic dosing in acute mania... 

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