Summary Grignard Reactions

Recall from Section 9-7 how acetylide ions are alkylated by displacing unhindered alkyl halides. 

Like acetylide ions, Grignard and organolithium reagents are strong bases and strong nucleophiles. Luckily, however, they do not displace halides as easily as acetylide ions do. If they 

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Key Mechanism 10-1 Grignard Reactions 443 Summary Grignard Reactions 450 10-10 Side Reactions of Organometallic Reagents Reduction of Alkyl Halides 451... 

In equation 1, the Grignard reagent, C H MgBr, plays a dual role as reducing agent and the source of the arene compound (see Grignard reaction). The Cr(CO)g is recovered from an apparent phenyl chromium intermediate by the addition of water (19,20). Other routes to chromium hexacarbonyl are possible, and an excellent summary of chromium carbonyl and derivatives can be found in reference 2. The only access to the less stable Cr(—II) and Cr(—I) oxidation states is by reduction of Cr(CO)g. 

Glycols, summary of chemistry, 294 Grignard reaction, 258, 269, 335 with C=0 groups, 335, 353 limitations, 260 with water and D2O, 57 Grignard reagent, 56 Ground state, 230... 

In summary, the following arc important differences between surface-molecule pairs ZB and tnoiccule-moleeule pairs AB. Perhaps the most important lesson here is that the absence of solvent attiick in a Grignard reaction is not evidence that... 

Mechanism 14-4 Base-Catalyzed Opening of Epoxides 653 14-14 Orientation of Epoxide Ring Opening 654 14-15 Reactions of Epoxides with Grignard and Organolithium Reagents 656 14-16 Epoxy Resins The Advent of Modern Glues 656 Summary Reactions of Epoxides 658 EssentialTerms 660 Study Problems 662... 

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