Sumatriptan Propranolol

Drugs that affect nefazodone include general anesthetics, sibutramine, sumatriptan, buspirone, carbamazepine, and propranolol. Drugs that may be affected by nefazodone include alcohol, benzodiazepines, buspirone, carbamazepine, cisapride, digoxin, haloperidol, HMG-CoA reductase inhibitors, MAOIs, propranolol, St. John s wort, cyclosporine, and tacrolimus. 

In a study in 10 healthy subjects, propranolol 80 mg twice daily for 7 days did not alter the pharmacokinetics of a single 300-mg dose of sumatriptan given on day 7. There was no significant effect on pulse rate or blood pressure. ... 

Scott AK, Walley T, Breckenridge AM, Lacey LF, Fowler PA Lack of an interaction between propranolol and sumatriptan. (1991)32, 581-4. 

Paroxysmal Disorders. Migraines are paroxystic, intense hemicranial pain episodes, accompanied by vomiting and light sensitivity. The cause of these episodes is still unclear. Acute treatment of migraine employs drugs such as sumatriptan and ei otamine, while prophylactic therapy uses various agents such as propranolol, verapamil, amitriptyline, and valproate. 

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